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The XXth Gamow conference-school is devoted to: – the 155-th anniversary of the Odessa I.I.Mechnikov National University – the 55-th anniversary of the discovery of cosmic microwave background radiation of the Universe – the 140-th anniversary of prof. A.Ya.Orlov (Head of the Odessa Astronomical Observatory in 1913–1944) – the 170-th anniversary of prof A.K.Kononovich (Head of the Odessa Astronomical Observatory in 1881 – 1911). Georgij (George) Antonovich Gamow is one of the greatest physicists and cosmologists of the 20th century. Gamow made an important and decisive contribution to modern physics, cosmology and biology. His three most significant contributions to these fields are: He discovered the quantum nature of alpha-decay in nuclear physics (1928). He proposed the theory of the Hot Universe (1946-1953). He found the clue to the genetic code in biology (1954). George Gamow was born in Odessa. Here, he leaved the secondary school and was for two years a student of the Novorossiisk University of Odessa. Wherever Gamow lived, he retained his character and his sharp Odessian humor. During the conference, participants will be able to visit the sights of Odessa, to see and feel its colour and to walk along the Gamow places described in his book “My World Line: an Informal Autobiography”