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Join leading academic researchers, scientists and engineers from membrane desalination and associated industries as well as representatives of government organisations, international agencies and aid organisations to discuss the latest developments in desalination using membrane technology. The conference scope will include theoretical and applied research, technological and industrial development. Growing population, changing climate and increasing urbanisation require increasing freshwater supply and the sustainable water usage for industries and agriculture is of top priority. One of the most viable solutions is to tap from the seawater and wastewater. Membrane technologies have been established as the golden standard for desalination to address the global deficit for clean water. However, it is still expensive, which is one of the main obstacles for prevalent adoption of membranes. Innovation is key to reduce the energy consumption and the total cost. This can be advanced by developing high performance reverse osmosis (RO) and nanofiltration (NF) membranes, robust module and process design, as well as other novel desalination technologies. We have seen promise in breaking the permselectivity trade-off using state-of-the-art nanomaterials. Biomimetic single ion channel and artificial water channel have shown exciting results in bench tests. The Fifth International Conference on Membrane Desalination 2021 (MEMDES 2021) is the dedicated forum to disseminate the cutting-edge research and development in this regard. Beyond above challenges, environmental concerns are also important for sustainable membrane desalination. Harvesting valuable resources from brine has been a new direction for desalination, by highlighting the critical importance of ion selective membranes. The organising committee welcomes contributions from all fields focusing on membrane desalination and associated issues either in fundamental or applied research and applications. This conference is also open to the representatives of government organisations, international agencies and aid organisations to inform governments and stakeholders on the key progress, research findings and newest development for strategic and policy reference. Topics include: Covid-19 impact in desalination Reverse osmosis, nanofiltration, forward osmosis, pressure retarded osmosis Biomimetic water and ion channel membranes Ultrafiltration, microfiltration Membrane fouling and control Pre-treatment and post-treatment processes Membrane distillation, pervaporation Emerging desalination technologies Electrochemical systems Novel hybrid systems and module design Brine/concentrate management Resources recovery from brine Energy and sustainability, economic evaluation, case studies