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PRES’21 is the 24th conference founded in collaboration with Prof Zdenĕk Burianec, initially jointly with CHISA congresses. The PRES conference series represent recognised platform for bringing together scientists, engineers and decision-makers, to discuss and to innovate solutions and technologies for improved efficiency and sustainability of industrial and regional systems. The aim of the PRES conference Is to stimulate and to facilitate scientific networking, mutual enrichment and technological development in the field of processes integration for energy saving, pollution reduction and related topics on sustainability and the circular economy. Industrial topics are particularly welcomed. There are 500 – 600 experts participating each year. This year conference edition is organized by the Brno University of Technology, Faculty of Engineering, in its hometown of Brno in the Czech Republic as a “hybrid” from October 31st to November 3rd 2021. We all hope that by November 2021, the COVID-19 crisis would be under control. However, the organisers take the safety arrangements very seriously and they will monitor the situation closely. Updated info will be published here on this website. PRES has a long tradition of promoting excellence in poster presentations. In 2018, a new SPIL Young Speakers Award, sponsored by SPIL Project at VUT Brno, CZ, was added. Awards include certificates, Sustainability and Process Integration books, and invitations to submit to one of the Special Issues.