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As science becomes increasingly interdisciplinary, the Biophysical Society Annual Meeting continues its long-held reputation for bringing together leading scientists from the all over the world who work at the interface of the life, physical, and computational sciences. The dynamic five-day meeting provides attendees with opportunities to share their latest unpublished findings and learn the newest emerging techniques and applications. Despite its nearly 5,000 attendees, the Meeting is noted for maintaining its “small meeting” feel beginning with the Saturday Subgroup symposia, which allow attendees to meet within their scientific communities. It is also known for its vitality, demonstrated by the over 800 highly interactive daily poster presentations, the more than 500 speakers selected from submitted abstracts, the many career development programs for those working in academia, industry, and agencies throughout the world, and its advocacy and education programs.