![]() |
ИСТИНА |
Войти в систему Регистрация |
ИСТИНА ЦЭМИ РАН |
||
Antibiotics have revolutionized modern medicine and established unprecedented patterns of public and animal health. However, their misuse has exposed bacteria to selective pressure, leading to the development of critical and therapeutically untreatable bacterial resistance. Our current arsenal of effective antibiotics accompanied by the lack of alternatives is prompting the beginning of the “post-antibiotic era”, which threatens all the achievements of modern medicine. The worldwide spread of multidrug-resistant bacteria is increasingly drawing global surveillance from authorities and the media due to its potentially catastrophic implications. The pharmaceutical industry’s limited interest in the discovery of new antibiotics or developing new therapeutic strategies is a critical issue, despite considering the impact such new developments may have on investment returns. Bacteria have demonstrated a rapid ability to develop resistance mechanisms to every new antibiotic. Considerable technological advances, particularly these omics, have allowed for the thorough investigations into and characterization of the mode of action and resistance of antibiotics. Considering the rate of demand, such advances seem to be insufficient in discovering novel antibiotics. Specific and targeted actions are needed to ensure antibiotic sustainability and halt the advance of the “post-antibiotic era”. While the discovery of innovative therapeutic solutions and the comprehension of their action mechanism is fundamental, patient access requirements need to be properly integrated. SARS-COV-2 highlighted the existing interactions between viral and bacterial/fungal infections. However, both the COVID-19 pandemic and Ukrainian/Russian conflict causing a shortage in amoxicillin have presented an unfortunate realization of what the global health situation may become once all commercial antibiotics fail to treat bacterial infections. The 3rd International Electronic Conference on Antibiotics will encourage the scientific community and stakeholders to present and discuss recent advances in antibiotic research.