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Following CAREX’s approach to research on life in extreme environment, the conference will be a truly interdisciplinary event. Oral presentations and posters will consider microbes, plants and animals evolving in various marine, polar, terrestrial extreme environments as well as outer space. It will be a unique opportunity to network and elaborate on cross-disciplinary scientific challenges. This conference and the call for papers will be structured around five overarching themes: Theme 1: Stressful environments – responses, adaptation and evolution • How do organisms escape the stresses of extreme environments? • Are there unique/common paths for responses to stresses? • How have proteins and genomes evolved under extreme conditions? • How diverse are the community-level responses to stresses? Theme 2: Biodiversity, bioenergetics and interactions in extreme environments • What characterises biodiversity in extreme environments? • How diverse are bioenergetic processes in extreme environments? • What characterises the nature and extent of biotic and abiotic interactions in extreme environments? Theme 3: Contributions of life in extreme environments to biogeochemical cycles and responses to environmental change • What was the role of life in extreme environments in defining the biogeochemical characteristics of the Earth? • What is the contribution of biogeochemical processes in extreme environments to the modern Earth system? • How resilient is life in extreme environments to environmental change? Theme 4: Life and habitability • What are the physico-chemical boundary conditions for habitability? • Where are the terrestrial analogues for putative extraterrestrial habitats? • What bio-signatures facilitate life detection? Theme 5: Technology Development • Sensor technology • Life detection • Molecular tools