ИСТИНА

Substantial number of pathogenic microorganisms resistant to small molecule of antibiotics causing the need for new substances with antimicrobial activity, lacking the drawbacks of traditional antibiotics. The use of bacteriophage enzymes that destroy bacterial cell wall is of particular interest. Enzymes LysK of bacteriophage K, specific towards staphylococci, and S 394/1, specific for Salmonella and E. coli, their properties, especially the lysis of pathogens, stability and the possibility of stabilization using polyelectrolytes are discussed. Possibilities of creating stable and effective enzyme preparations treating bacterial infections are discussed. Peculiarities of the structure of the cell wall of Gram-negative bacteria dictate, in particular, the need for additional helpers "disordering" outer cell membrane. One of the approaches developed describes the introduction of additional antimicrobial peptides, helping the antibacterial enzyme. Another approach is the use of magnetic nanoparticles in the form of "sticks", adsorbed on the cell wall of pathogens, "disordering" under the effect of low-frequency magnetic fields the outer membrane of pathogens and allowing the antibacterial enzyme more efficiently destroy the peptidoglycan of bacterial cell wall.