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The continuing global warming and the growth of climate extremes are strongly identified in the Northern and Arctic areas. Northern territory is 68% of Russia. For Northern territories the main factor of their sustainable development is the natural and climatic discomfort of the life conditions. In this regard, the urgency of using regionalization of Russia and the natural conditions of human life for assessing the conditions of the modern climate and forecasting the living conditions of the population for the future climate, is growing. Investigation of natural and climate conditions in the Northern and Arctic areas of Russia was conducted using the method of regionalization of Russian Federation territory by environment conditions of human life. The regionalization is made on the base of influence degree of the main natural factors: colds, heat, moisture, altitude, catastrophic events (hydrometeorological, seismic, geocriological). Four zones with unfavorable or favorable influence on the health, living, and labor activity of the population are determined: I – absolutely unfavorable; II – very unfavorable; III – unfavorable; IV – conditionally unfavorable. We have analyzed nature conditions of human life in the second part of the 20th century and their changes in the middle of the 21th century. As a result of the warming in 1991–2010 there was a significant reduction of the territory with absolutely unfavorable and very unfavorable conditions. The amount of the reduction was similar to the change of discomfort in the "hard" anthropogenic scenario for the period 2046–2055.