ИСТИНА

Purpose: To investigate the choroidal thickness (CT) in healthy individuals and its relation to potentially influencing factors. Methods: 105 healthy subjects/eyes underwent CT measurement with SS-OCT (DRI-OCT Triton, Topcon). CT was assessed in 9 sectors of the MZ. BMI, refraction and systemic diseases (arterial hypertension, diabetes, apnea) were considered as influencing factors. 9 participants (18 eyes) from the group were chosen for consequent examinations at 8 AM and PM. Results: The thickest choroid was in fovea (293±95µm) and superior para- (289±86µm) and perifovea (287±84µm). Simple linear regression analysis didn’t reveal an association of foveal CT (fCT) or mean macular CT (mmCT) with sex (R=0,16, p=0,108 and R=0,04, p=0,75) and refraction (R=0,13, р=0,17 and R=-0,007, р=0,95). fCT and mmCT were negatively correlated with age (R=-0,517, р<0,0001 and R=-0,56, р=0,0001) and BMI (R=-0,271, р=0,005 and R=-0,245, р=0,012). Each of the systemic disease was independently associated with thinner fCT and mmCT. In the multiple regression analysis only age and refraction were related to fCT and mmCT. The prospective study did not reveal significant diurnal CT variation. However, the greater amplitude of diurnal fCT change was associated with thicker choroid. Conclusions: The present study describes macular CT topographic variations in healthy eyes. Taking into account association with age, this study suggests the normal CT range measured with SS-OCT for three age groups. fCT: 253-449µm for age 20-39, 171-371µm for age 40-59, 142-283µm for age 60+; mmCT: 224-376µm for age 20-39, 161-317µm for 40-59, 120-234µm for 60+.