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Mesenchymal stem/stromal cells (MSC) are able to regulate tissue repair after injury including the prevention of excessive fibrosis. Extracellular vesicles (EV-MSC) were shown to mediate most of MSC effects and could be involved in their antifibrotic aсtivity. However, the mechanisms of these effects, particularly the role of microRNA (miR) within EV-MSC, are poorly understood.