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Here we introduce an innovative compact solution for diesel engines – “Four-Way” combined catalyst (FW CombiCat). The main idea was to integrate oxidation and reduction catalysts in a single compact unit to oxidize CO, HC, PM into CO2, and to reduce NO by NH3 into N2 simultaneously. Recently we have shown that such approach can be successively applied: CombiCats prepared by mechanical mixing Mn-based and zeolite-based components demonstrate favourable activity in NOx–PM and NOx–NH3-slip removal. This study was focused on two main aspects: (1) simultaneous removal of NOx, CO, HC, PM and NH3-slip over CombiCat; (2) possible interferences between reduction and oxidation processes.