ИСТИНА

Spatial pre-organization of the receptor component is a key factor governing the proper 3D arrangement of the participants of the supramolecular assemblies. Widely known are several quite effective classes of supramolecular host systems like crown-ethers, calixarenes, cucurbituriles and others. Among others, we would like to mention 3,7-diazabicyclo[3.3.1]nonanes, aka «bispidines». Indeed, in this system one could easily functionalize almost all positions of the bicyclic core, particularly, both nitrogens and carbon at position 9, aiming to decorate the molecule to fulfill the desired task. During the lecture the audience will have an opportunity to listen to our recent results on the study of the properties of various bispidine-based systems (conformations, biological activity, radiocopper, gels, chiral ligands, etc.),1,2 including their use to support the concept of «stereoelectronic chameleons».3 The authors are grateful to the Russian Science Foundation for the financial support of these studies (grant # 19-73-20090). References 1. Vatsadze et al: Mendeleev Commun 1999, 3, 87-88; Tetrahedron 2014, 70, 7854-7864; Mendeleev Commun 2016, 26, 212-213; ACS Omega, 2016, 1(5), 854-867; Nanomaterials 2019, 9, 89-106. 2. Volcho et al: Med Chem Res 2015, 24, 4146-4156; Russ J Bioorg Chem 2015, 41(6), 657-662; Bioorg Med Chem Lett 2017, 27, 4531-4535. 3. Alabugin, Vatsadze et al: Chem Eur J 2017, 23(14), 3225-3245; JACS 2018, 140(43), 14272-14288.