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The aim of this work is to analyze the long-term dynamics of soil contamination with potentially toxic elements (PTEs) in Moscow, as Moscow is one of the most polluted cities of Russia. The basis for assessing the pollution of soils with As, Cd, Pb, Zn, Hg, Cu, Ni, Mn was the annual monitoring data for 2007-2016, which is obtained by the «Mosecomonitoring» institution and include more than 2000 points of observation. An analysis of the changes in the pollutant content in the soils of Moscow over the decade showed a twofold increase in the accumulation of Cu, Cd, As in the Central District and Cd in the Western and Northwest ones, as well as As in the northeastern part of the city by 1.4–2.3 times. In all districts, a tendency toward a decrease in pollution with Zn, Pb, and Hg was revealed. Compared with 2007, in 2016, the average content of all PTEs in the soils of the city decreased or remained unchanged, except for As. The spatial distribution of PTEs in Moscow soils is controlled by the intensity and geochemical specialization of pollution sources, and varies due to soil properties. Central, Eastern, South-Eastern Districts are leading in terms of Cu and Pb pollution. Central and South-Eastern Districts are distinguished by Hg pollution. Central, North-Eastern, South-Eastern, and Southern Districts are most polluted with Zn and Cd. Soils in the southern part of Moscow are most enriched in Ni. High concentrations of As are characterized by soils of light grain-size composition with a high content of organic matter.