ИСТИНА

Due to the global problem of an aging human’s population, a need of various regenerative materials, in particular a bone implants demand, inevitably arises. Since the emphasis is placed on the regenerative approach to bone tissue neogenesis, ceramic materials based on magnesium phosphates included in the MgNaPO4–Mg3(PO4)2 system are promising materials for these purposes. Because of the quite complex hierarchical structure of the bone, these implants meet relevant requirements. In the ideal case, the material should be resorbable, osteoconductive, osteoinductive and have high mechanical characteristics. Today there is no material, which could satisfy all these requirements. Therefore, the main emphasis is made on the great solubility of the material. Magnesium-sodium phosphates from the considering system must have greater solubility compared to the currently used materials based on hydroxyapatite (HA) and tricalcium phosphate (TCP), due to the significant contribution of the enthalpy of solvation of the magnesium ion, which overlaps the contribution of the small ionic radius. Moreover, magnesium phosphates have special biological features. These include suppressing the proliferation of osteoclasts and their homeostasis with release magnesium ions during the phosphate’s dissolution, as well as improving the adhesion of osteoblast (bone-building cells) to the material and their proliferation. The aim of this work is to develop ceramic materials for osteoplastic with greater solubility compared to HA and TCP based on magnesium and sodium phosphates in the MgNaPO4– Mg3(PO4)2 system. In this work we consider the problems of dense ceramic materials obtaining that can be studied and resolved using thermal analysis methods. In particular, in the process of work • The phase relations in this two-component system were investigated using the methods of STA, dilatometry and high-temperature X-ray powder diffraction; • The quantities of phase transitions of the MgNaPO4 as well as their temperatures and volume effects were determined; • The temperature conditions for fabrication of dense ceramics based on magnesium-sodium phosphates are determined. Acknowledgements The financial support of the Russian Science Foundation as part of the 19-19-00587 project.