ИСТИНА

Ischemia and reperfusion (I/R) of kidney is one of the leading causes of the acute kidney injury (AKI). I/R leads to mitochondrial dysfunction and overproduction of reactive oxygen species. Oxidative stress could affect endothelial function and this may be explanation for deterioration of renal hemodynamics observed during AKI. The aim of this work to study the ability of mitochondria-targeted antioxidant SkQR1 to prevent endothelial dysfunction of kidney during I/R. Conclusions: Mitochondria-targeted antioxidant SkQR1 attenuates endothelial dysfunction and renal failure after ischemic AKI.