ИСТИНА

Keratouveitis is an inflammatory condition of the eyes characterized by keratitis and anterior uveitis. Also, keratouveitis refers to a clinical picture of active corneal disease associated with anterior chamber inflammation. We have developed an experimental model of UV-induced keratouveitis, which can allow us to study the therapeutic effectiveness of drugs for the treatment of this pathology. Because the inflammation diseases are triggering by proinflammatory cytokines production through promoting the production of mitochondrial reactive oxygen species, in this work, the feasibility of mitochondria-targeted antioxidant SkQ1 based therapy for enhancement of keratouveitis prevention after UV irradiation was investigated in vivo.