ИСТИНА

Hyperuricemia (GI) is a risk factor leading to the development of socially significant diseases. The frequency of occurrence of hyperuricemia and associated conditions is constantly increasing, therefore, it seems extremely important to early detection and monitoring of patients with asymptomatic hyperuricemia and comorbid pathology. One of the approaches to screening patients is questionnaires that influence the development of diagnostic and therapeutic tactics. Questionnaires are also used as criteria for evaluating the results of clinical trials, so it is of fundamental importance that the instrument used is properly designed and tested. The objective. Development of a questionnaire in order to identify patients with hyperuricemia and articular syndrome at the outpatient stage. Materials and methods. The first retrospective part of the study included 89 case histories of patients observed at the MREC of MSU from 2016 to 2019 with diagnoses of "Hyperuricemia without signs of inflammatory arthritis and gouty nodes", "Gouty arthritis" and "Chronic heart failure". The second part of the work included a closed questionnaire survey of 62 patients, conducted from 03.01-03.20 2020 at the MREC of MSU and in the clinic named after E.M. Tareev of the I MSMU named after I.M. Sechenov. Statistical data processing was carried out using the Statistica 12 software package. Results. Based on a retrospective analysis of 89 case histories of patients aged 37 to 94 years (mean age 71 ± 8 years; 44 women (49%) and 45 men (51%)), a system of questions was developed that allows at the outpatient stage of the examination, identify patients with probable hyperuricemia and a high risk of developing cardiovascular diseases. The testing of the questionnaire was carried out on 62 patients who applied for an outpatient appointment with a rheumatologist with articular syndrome. The sensitivity of the developed questionnaire was 86.7%, the specificity was 95.7%. Discussion. The revealed patterns are consistent with the data of other authors, which indicate a frequent association of GI with cardiovascular diseases, kidney damage, the development of metabolic syndrome: excess body weight, arterial hypertension, insulin resistance. The analysis of the presence of disability in the respondents with joint syndrome showed that most of them did not have dependence on the level of uric acid. This is probably due to an insufficient sample, since joint syndrome is a polymorphic pathology that accompanies various auto-inflammatory and degenerative diseases. Conclusions. The developed questionnaire turned out to be an adequate and reliable screening method that makes it possible to identify patients with impaired purine metabolism at the outpatient stage in the presence of articular syndrome.