ИСТИНА

Over the past decade, a regenerative approach to bone tissue engineering has developed significantly by evolving the construction of bulk polymer scaffolds in combination with bioactive components that can stimulate the differentiation of donor stem cells into osteoblasts. Since the modern materials for the cell structures cultivation in vitro and for the drugs delivery to the area of bone tissue damage cannot be fully recommended for use, the search for new materials for these medical purposes, as well as methods of their manufacture is an urgent problem for research in the field of interdisciplinary materials science. Composite materials, including a composite polymer matrix based on polyvinyl alcohol (PVA) and chitosan (Ch), and particles of synthetic calcium phosphates and carbonates (CP and CC) allow us to find an approach to solving the above-mentioned problem. Thus, the aim of this study was to develop film and fibrous materials based on PVA/Ch hydrogels filled with calcium salts. The following tasks were set to achieve the goal: to study the physical and chemical properties of composite PVA (M 120 kDa) and Ch (M 190 kDa) solutions; to develop a strategy for the synthesis of bioresorbable CP (Ca/P = 1; 1.67) and CC in viscous polymer solutions; to obtain films and fibers of composite hydrogels ‘PVA/Ch/CP/H2O-CH3COOH’ and ‘PVA/CP/CC/H2O’, and to study the properties of samples for phase composition, filler morphology and cytocompatibility.