ИСТИНА

Cancer development and progression are often followed by changes in expression levels of different long non-coding RNAs (lncRNA). These cancer-associated lncRNAs are widely considered as perspective tools in early diagnostics of carcinogenesis, probable targets for cancer therapy or prognostic biomarkers. However, thorough investigation of lncRNAs and their functions is often limited due to the lack of appropriate animal models. LncRNAs usually share poor sequence homology between species, which implies difficulties in the identification of murine candidates. Moreover, analogous lncRNAs from human and mice often participate in different cellular pathways. In the present work we characterized a novel human lncRNA CHOL, which ismiserably expressed in different human tissues, but is up-regulated in cholangiocarcinoma (CCA) and pancreatic duct adenocarcinoma cancer (PDAC) tissues (in comparison to adjacent liver or pancreas samples, respectively).