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ИСТИНА ЦЭМИ РАН |
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Nanoemulsions for water insoluble anticancer drugs, taxanes, are developed and investigated. Stabilizing agents are suggested to delute taxane-containing emulsion with infusion solution for parenteral infusion. In vitro study on multicellular tumor spheroids (MTS) and monolayer culture demonstrated the cytotoxicity of docetaxel-loaded lyophilized nanoemulsion to be more effective in comparison with commercial dosage form.