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More than 200 years ago, there were claims that intensive shaking of aqueous solutions of biologically active substances leads to such a change in the properties of these solutions that even after their repeated successive dilution, they retain their biological activity. In recent years, in a number of laboratories, using modern methods of analysis, studies have been conducted on the effect of mechanical action on water and its aqueous solutions on the physico-chemical properties of water systems. It was found that after such effects, the properties of the physicochemical properties of these systems change. In particular, reactions involving reactive oxygen species begin to occur intensively in them, which increases their biological activity, their spectral properties, and their buffer properties. We found that the properties of water during its sequential "dilution" as well as the properties of aqueous solutions of hydrated fullerene C60 change up to dilutions equivalent to the calculated concentration of fullerene 10(E-31)M. At the same time, the properties of pure water change in the same direction as fullerene solutions, but the duration of these changes in water and their severity are significantly lower than in high dilutions of fullerene. Possible physicochemical mechanisms of these phenomena are discussed.