ИСТИНА

Aliphatic polyesters based on hydroxyacids – lactic, glycolic, etc. are widely used in medicine due to their biocompatibility and ability to decompose into non-toxic and easily excreted compounds. During the last decade attention of researches is devoted to amphiphilic aliphatic polyesters due to their biocompatibility and good surface properties. In course of degradation of such polymers mainly natural metabolites are formed, that makes their use in medicine and biotechnology are particularly attractive. Such polymers, having hydrophobic polymer blocks formed by hydroxyacids, and hydrophilic ones by polyethylene oxide and polyglycerols, may present new biocompatible and biodegradable surface- active compounds that are able to withdrawn from the body rapidly and completely. In this work, a series of new block copolymers based on hydroxy acids was synthesized and studied, as well were defined their physico -chemical and surface properties. All synthesized amphiphilic block copolymers possess pronounced surfactant properties, depending on the ratio of the hydrophilic and lipophilic moieties the macromolecule, as well as the structure of the copolymer. We present the sucessful usage of synthesized aliphatic polyester-based biodegradable copolymers as surfactants in the preparation of microemulsions, microcapsules and microparticles. It was established that the droplet size for emulsions stabilized by branched copolymers grew more slowly than for emulsions, stabilized by the linear ones. Microcapsules, formed using the branched copolymers as surfactants, show higher encapsulation efficiency and smother particle surfaces compared to ones, formed using the linear copolymers.