ИСТИНА

In our study, we performed 2-hour inhalation with argon and krypton for 3 days. Animals were randomly divided into 3 groups: control group with stroke + N2 inhalation n=10; experimental group with stroke + Ar inhalation n=8; experimental group with stroke + inhalation Kr n=10. Neurological status was assessed using the protocol described by De Rieck et al. (1989) and modified by J. Jolkkonen et al. (2000) An MRI study and euthanasia of the animals were performed on the 14th day after the stroke. The degree of brain damage was assessed by analysis of MRI images. The rat brain was sent for histological examination. Inhalation with argon and krypton had a significant impact on the studied parameters. The mean damage volume in the stroke+iAr group and the stroke group was 11.3 (8.8;16.6) mm3 and 20.7 (16.7;23.79) mm3, statistically significant differences between the groups (p = 0.01) . Histological examination in the Stroke group on the 14th day shows typical changes in ischemic damage. In the nitrogen group, a shaft of glial cells is pronounced, destroying dead and damaged cells, in addition, a large number of foam cells are noted in the tissue structure, which absorb altered cells, trigger apoptotic mechanisms and then, at a later date, die, forming fibrous tissue, which underlies scar formation. Also in this group, newly formed vessels are visible, which are located on the periphery. There are no signs of capsule formation at this stage yet. In the Stroke + iAr and Stroke + iKr groups, signs of encapsulation are already noted, the newly formed vessels are already located in the thickness of the necrosis area, and not on the periphery. All this indicates the acceleration of tissue repair processes after ischemic injury.