ИСТИНА

Recent advances in biomedical imaging techniques, such as ongoing implementation of photon-counting computed tomography (PCCT), triggered the need for development of novel classes of the contrasting agents (CA). Special attention is devoted to CA that could be used in multiple types of imaging studies dramatically enhancing their experimental and diagnostic capabilities. Among such CA, Gd-based nanoparticles with core-shell structure are considered the most promising due to their usability for both magnetic resonance imaging (MRI) and CT/PCCT combined with variability in size, morphology, and functionalization capabilities allowing to tailor their physico-chemical and pharmacological properties.