ИСТИНА

Hybrid nanosystems based on stabilized silver nanoparticles (SNPs) attract the attention of researchers due to their unique optical, structural, morphological, mesogenic, adsorption properties. Atoms and small clusters obtained as a beam using thermal evaporation of bulk metal under high vacuum conditions and followed by condensation on cooled support surfaces of different preparative cryostats possess a high chemical reactivity as compared to that of bulk metals. SNPs with size of 2-3 nm can interact with cholesteric molecules forming hybrid linear aggregates (length 10 μ) which possess plasmonic collective absorbtion in the visible range of wavelengths. Cholesterol is an important biomolecule and an essential component of most biological membranes and serves functions in controlling membrane integrity, organization and signaling. Moreover cholesterol and it’s derivatives thiocholesterol have unique liquid crystalline properties. The use of hybrid nanosystems based on SNPs-cholesterol and SNPs-thiocholesterol opens up new and promising ways for research. One of them is using such systems in direct drug delivery. It’s well known that SNPs have a strong antibacterial properties. Stabilization of SNPs with mesogenic liquid crystalline molecules leads to the formation of small spherical particles with average size (5.5±1.0) nm in case of cholesterol and (2.7±0.6) nm in case of thiocholesterol. This approach allows to use such systems for targeted drug delivery improving bioavailability and efficiency. Moreover the practical interest to these systems stimulates the need for theoretical modeling developing primarily with modern quantum-chemical calculations.