ИСТИНА

In the human (animal) organism, the microbiota is directly or indirectly involved in a wide variety of metabolic, behavioral, and communicative activities of the host. An important communication channel is based on neuromediators. The ongoing microbiota—host communication is bidirectional. Various microorganisms are known to both produce, and respond to, neurochemicals, including neuropeptides, amino acids, biogenic amines, and gaseous substances. The human intestinal symbiotic bacterium Lactococcus lactis subsp. lactis produces bioactive molecules, such as organic acids, bacteriocins and other antimicrobial agents, as well as neurochemicals including biogenic amines(serotonin, norepinephrine, epiphrine). The microbially synthesized neuromediators are expected to influence the nervous and the immune system of the host and to perform regulatory functions inside the microbial community of the host organism.