ИСТИНА

Using the method of metal-vapor synthesis (MVS), new hybrid materials based on collagen (Coll)/ collagen-chitosan scaffolds (CollChit) and conjugates of dihydroquercetin (DHQ) with silver nanoparticles (AgNPs) were obtained. The materials were characterized by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD), X-ray photoelectron spectroscopy (XPS). An evaluation of the crystallite sizes of Ag by the Sherrer method with PXRD data gives 23 nm for Coll-AgNPs and 12 nm for Coll-AgNPs@DHQ. In contrast to AgNPs obtained by metal vapor synthesis with a single Ag0 state, XPS measurements detected three states in AgNPs@DHQ and Coll-AgNPs@DHQ conjugates. The AgNPs@DHQ sample showed general cytotoxicity inhibiting the metabolic activity and vitality of both normal and tumor human cell types. The study showed good prospects for the biomedical use of the Coll-AgNPs@DHQ system which exhibited good biocompatibility, selective antitumour properties and antioxidant activity.