ИСТИНА

This study demonstrated that tetra-meso-substituted P(V) porphyrins (with the number of -Py n=0-2) with axial -OH groups undergo dephosphory-lation at pH = 7.4 in the presence of FBS, as evidenced by the change in fluorescence (Fig. 1a). In contrast, similar complexes with axial -OEt and -OPrOH groups remained in the initial state (Fig. 1b). Using dephosphorylation of hydroxyl-complexes in cells, the cytotoxicity of free-base porphyrins and their complexes can be compared. P(V) complexes exhibit greater light-induced cytotoxicity than corresponding free-base porphyrins. Among them, [(ТРР)P(OEt)2]+ and [(MPyР)P(OEt)2]+ are the most promising for PDT, with nanomolar IC50 values.