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Preeclampsia (PE) is a complication of pregnancy characterized by proteinuria (>0,3 g/day) and hypertension (140/90 mm Hg). The placenta protects the fetus from viruses and bacteria mainly by means of factors of non-specific resistance and innate immunity such as pattern-recognition receptors: NOD-like and TLR-like receptors. However there are typically immune tolerance disturbances in women with preeclampsia, but the role of antiviral protection receptors (NOD-1, TLR9) is still unknown. Besides to viral derivatives a few literature data suggests fetal DNA may serve as TLR9 ligand.