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BI-SPECIFIC AFFINITY REAGENTS FOR CELL-LINEAGE-SPECIFIC TNF-ALPHA NEUTRALISATION патент
- Авторы: NEDOSPASOV, Sergej; KRUGLOV, Andrej; EFIMOV, Grigory Alexandrovich;
- Номер: WO2014064287
- Дата публикации патента: 1 мая 2014 г.
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Реферат (описание изобретения):
The invention relates to isolated bispecific affinity reagents, such as antibodies or antibody fragments that bind TNFα and a marker molecule for macrophages and/or neutrophils. The affinity reagents of the invention enable pathogenic sub-populations of TNFα to be neutralised, whilst protective sub-populations of TNFα are not affected.
- Добавил в систему: Ефимов Григорий Александрович