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Pharmacokinetic and pharmacodynamic synergism between neuropeptides and lithium in the neurotrophic and neuroprotective action of cerebrolysinстатья
- Авторы: Gromova OA, Torshin II, Gogoleva IV, Pronin AV, Stel'mashuk EV, Isaev NK, Genrikhs EE, Demidov VI, Volkov AI, Khaspekov GL, Aleksandrova OP
- Журнал: Zhurnal Nevrologii i Psikhiatrii imeni S.S. Korsakova
- Том: 115
- Номер: 3
- Год издания: 2015
- Издательство: Media Sphera
- Местоположение издательства: Russian Federation
- Первая страница: 65
- Последняя страница: 72
- Аннотация: To study the synergism between neuropeptides and lithium ions. MATERIAL AND METHODS: An experimental model of stroke (chronic bilateral occlusion of the common carotid arteries in rats), neuronal culture studies, histomorphological analyses, determination of micronutrient profile of brain substrates were used. RESULTS: A complex of experimental studies revealed that the effect of cerebrolysin is influenced by the synergism between lithium ions and the neuropeptide content of this drug. Pharmacokinetic synergism promotes the accumulation of lithium in brain tissues during cerebrolysin treatment. The existence of the pharmacokinetic synergism is evident from the potentiation of neuroprotective effects of the drug under the action of lithium ions established in the model of stroke.
- Добавил в систему: Исаев Николай Константинович