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Non-viral Transfer of BDNF and uPA Stimulates Peripheral Nerve Regenerationстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 2 декабря 2015 г.
- Авторы: Maxim Karagyaur, Daniar Dyikanov, Pavel Makarevich, Ekaterina Semina, Dmitry Stambolsky, Olga Plekhanova, Natalia Kalinina, Vsevolod Tkachuk
- Журнал: Biomedicine and Pharmacotherapy
- Том: 74
- Год издания: 2015
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 63
- Последняя страница: 70
- DOI: 10.1016/j.biopha.2015.07.002
- Аннотация: Peripheral nerves connect brain and spinal cord with the extremities and inner organs, and nerves injury can lead the disability and social exclusion. Growth factors and other natural stimulators of regeneration processes look very promising as future medicines. In our study we tested the influence of genetic constructions that contain genes of brain-derived neurotrophic factor and urokinase plasminogen activator on nerve's structure and function after traumatic and ischemic injuries. Injection of pVax1-hBDNF and pVax1-muPA after traumatic injury led to better restoration of nerve's structure and function compared to similar parameters of control group mice. In ischemic injury model pVax1-hBDNF and pVax1-muPA slowed and reduced the damage progression and stimulated nerve regeneration as well. However, the treatment with pVax1-muPA was less effective after the traumatic injury. As we chose a non-viral method of gene delivery during our study the optimal conditions of plasmid intramuscular delivery were also determined.
- Добавил в систему: Калинина Наталья Игоревна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | uPA-BDNF-BioPha.pdf | 558,1 КБ | 16 июля 2015 [nikalinina] |