Mitochondria‐targeted antioxidant SkQ1 improves impaired dermal wound healing in old mice

Demyanenko, I.A.; Popova, E.N.; Zakharova, V.V.; Ilyinskaya, O.P.; Vasilieva, T.V.; Romashchenko, V.P.; Fedorov, A.V.; Manskikh, V.N.; Skulachev, M.V.; Zinovkin, R.A.; Pletjushkina, O.Y.; Skulachev, V.P.; Chernyak, B.V.

Статья опубликована в высокорейтинговом журнале

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 22 ноября 2015 г.

Авторы: Demyanenko I.A., Popova E.N., Zakharova V.V., Ilyinskaya O.P., Vasilieva T.V., Romashchenko V.P., Fedorov A.V., Manskikh V.N., Skulachev M.V., Zinovkin R.A., Pletjushkina O.Yu, Skulachev V.P., Chernyak B.V.
Журнал: AGING-US
Том: 7
Номер: 7
Год издания: 2015
Первая страница: 475
Последняя страница: 485
DOI: 10.18632/aging.100772
Аннотация: The process of skin wound healing is delayed or impaired in aging animals. To investigate the possible role of mitochondrial reactive oxygen species (mtROS) in cutaneous wound healing of aged mice, we have applied the mitochondriatargeted antioxidant SkQ1. The SkQ1 treatment resulted in accelerated resolution of the inflammatory phase, formation of granulation tissue, vascularization and epithelization of the wounds. The wounds of SkQ1‐treated mice contained increased amount of myofibroblasts which produce extracellular matrix proteins and growth factors mediating granulation tissue formation. This effect resembled SkQ1‐induced differentiation of fibroblasts to myofibroblast, observed earlier in vitro. The Transforming Growth Factor beta (TGFβ) produced by SkQ1‐treated fibroblasts was found to stimulated motility of endothelial cells in vitro, an effect which may underlie pro‐angiogenic action of SkQ1 in the wounds. In vitro experiments showed that SkQ1 prevented decomposition of VE‐cadherin containing contacts and following increase in permeability of endothelial cells monolayer, induced by pro‐inflammatory cytokine TNF. Prevention of excessive reaction of endothelium to the pro‐inflammatory cytokine(s) might account for anti‐inflammatory effect of SkQ1. Our findings point to an important role of mtROS in pathogenesis of age‐related chronic wounds
Добавил в систему: Захарова Влада Вячеславовна

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Mitochondria‐targeted antioxidant SkQ1 improves impaired dermal wound healing in old miceстатья

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