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"Dilute-and-Shoot" liquid chromatography tandem mass spectrometry method for fast detection of thiodiglycolic acid in urineстатья
Информация о цитировании статьи получена из
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 6 апреля 2016 г.
- Авторы: Timur Baygildiev, Arcady Braun, Andrey Stavrianidi, Igor Rodin, Oleg Shpigun, Igor Rybalchenko, Irina Ananieva
- Журнал: European Journal of Mass Spectrometry
- Том: 21
- Год издания: 2015
- Издательство: IM Publications
- Местоположение издательства: United Kingdom
- Первая страница: 733
- Последняя страница: 738
- DOI: 10.1255/ejms.1387
- Аннотация: New sensitive fast liquid chromatography tandem mass spectrometry (RSLC-MS/MS) approach for thiodiglycolic acid (TDGA) determination in urine has been developed. The use of "Dilute-and-Shoot" method helps to shorten sample preparation stage and provides a sensitive and direct approach for thiodiglycolic acid determination in urine. Chromatographic separation of the analyte and other urine compounds was achieved using a reverse phase LC column with mobile phases consisting of 0.1% formic acid in water and acetonitrile in gradient elution mode. For identification and quantification of TDGA electrospray ionization-tandem mass spectrometry monitoring two precursor-to-product ion transitions was used. The method demonstrates good linearity and has detection limit of 50 ng mL-1 in urine.
- Добавил в систему: Родин Игорь Александрович