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Naked mole rats can undergo developmental, oncogene-induced and DNA damage-induced cellular senescenceстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 10 августа 2018 г.
- Авторы: Zhao Yang, Tyshkovskiy Alexander, Muñoz-Espín Daniel, Tian Xiao, Serrano Manuel, de Magalhaes Joao Pedro, Nevo Eviatar, Gladyshev Vadim N., Seluanov Andrei, Gorbunova Vera
- Журнал: Proceedings of the National Academy of Sciences of the United States of America
- Том: 115
- Номер: 8
- Год издания: 2018
- Издательство: National Academy of Sciences
- Местоположение издательства: United States
- Первая страница: 1801
- Последняя страница: 1806
- DOI: 10.1073/pnas.1721160115
- Аннотация: Cellular senescence is an important anticancer mechanism that restricts proliferation of damaged or premalignant cells. Cellular senescence also plays an important role in tissue remodeling during development. However, there is a trade-off associated with cellular senescence as senescent cells contribute to aging pathologies. The naked mole rat (NMR) (Heterocephalus glaber) is the longest-lived rodent that is resistant to a variety of age-related diseases. Remarkably, NMRs do not show aging phenotypes until very late stages of their lives. Here, we tested whether NMR cells undergo cellular senescence. We report that the NMR displays developmentally programmed cellular senescence in multiple tissues, including nail bed, skin dermis, hair follicle, and nasopharyngeal cavity. NMR cells also underwent cellular senescence when transfected with oncogenic Ras. In addition, cellular senescence was detected in NMR embryonic and skin fibroblasts subjected to γ-irradiation (IR). However, NMR cells required a higher dose of IR for induction of cellular senescence, and NMR fibroblasts were resistant to IR-induced apoptosis. Gene expression analyses of senescence-related changes demonstrated that, similar to mice, NMR cells up-regulated senescence-associated secretory phenotype genes but displayed more profound down-regulation of DNA metabolism, transcription, and translation than mouse cells. We conclude that the NMR displays the same types of cellular senescence found in a short-lived rodent.
- Добавил в систему: Гладышев Вадим Николаевич