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In vivo optical imaging of the viable epidermis around the nailfold capillaries for the assessment of heart failure severity in humansстатья Исследовательская статья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 24 октября 2018 г.
- Авторы: Shirshin Evgeny A., Gurfinkel Yury I., Matskeplishvili Simon T., Sasonko Maria L., Omelyanenko Nikolai P., Yakimov Boris P., Juergen Lademann, Darvin Maxim E.
- Журнал: Journal of Biophotonics
- Том: 11
- Номер: 9
- Год издания: 2018
- Издательство: Wiley - VCH Verlag GmbH & CO. KGaA
- Местоположение издательства: Germany
- Первая страница: e201800066
- DOI: 10.1002/jbio.201800066
- Аннотация: Heart failure is among the socially significant diseases, involving over 2% of the adult population in the developed countries. Diagnostics of the HF severity remains complicated due to the absence of specific symptoms and objective criteria. Here we present an indicator of the HF severity based on the imaging tissue parameters around the nailfold capillaries. High resolution nailfold video capillaroscopy was performed to determine the perivascular zone (PZ) size around nailfold capillaries, and two-photon tomography with fluorescence lifetime imaging was used to investigate PZ composition. We found that the size of PZ around the nailfold capillaries strongly correlates with heart failure severity. Further investigations using two-photon tomography demonstrated that PZ corresponds to the border of viable epidermis and it was suggested that the PZ size variations were due to the different amounts of interstitial fluid that potentially further translates in clinically significant oedema. The obtained results allow for the development of a quantitative indicator of oedematous syndrome, which can be used in various applications to monitor the dynamics of interstitial fluid retention. We therefore suggest PZ size measured with nailfold video capillaroscopy as a novel quantitative sensitive non-invasive marker of heart failure severity.
- Добавил в систему: Мацкеплишвили Симон Теймуразович
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Полный текст | Shirshin_et_al-2018-JoB.pdf | 3,5 МБ | 9 июля 2018 [simonmats] |