Pulsed Electric Field-Induced Remote Decapsulation of Nanocomposite Liposomes with Implanted Conducting Nanoparticles

Gulyaev, Y.V.; Cherepenin, V.A.; Vdovin, V.A.; Taranov, I.V.; Yaroslavov, A.A.; Kim, V.P.; Khomutov, G.B.

Авторы: Gulyaev Yu V., Cherepenin V.A., Vdovin V.A., Taranov I.V., Yaroslavov A.A., Kim V.P., Khomutov G.B.
Журнал: Journal of Communications Technology and Electronics
Том: 60
Номер: 10
Год издания: 2015
Издательство: Maik Nauka/Interperiodica Publishing
Местоположение издательства: Russian Federation
Первая страница: 1097
Последняя страница: 1108
DOI: 10.1134/S1064226915100034
Аннотация: The results obtained in creating the new nanocomposite hybrid systems sensitive to external nonthermal electricfield pulses, which are created for the encapsulation, addressed delivery, and the controlled decapsulation of various substances in aqueous media, are presented. Such systems are based on liposomes containing electrically neutral biogenic lipids that are functionalized by conducting nanoparticles and polymers. The fabricated systems have been investigated using transmission electron microscopy, atomic force microscopy, electron magnetic resonance, laser light scattering, electrophoresis, and conductometry. The systems constructed under the action of short (on the order of 8 ns) electric pulses with high intensities (up to 100 kV/m) are found to exhibit the remote decapsulation effect. The model describing the mechanism of interaction between nanostructured liposomes with surface conducting nanoparticles and an external electric field leading to substantial changes in liposome structure is proposed. The critical values of the external electric field stimulating the decapsulation of nanocomposite liposomes are estimated with the help of the constructed model.
Добавил в систему: Хомутов Геннадий Борисович

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Pulsed Electric Field-Induced Remote Decapsulation of Nanocomposite Liposomes with Implanted Conducting Nanoparticlesстатья

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