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Chimeric particles of Tobacco mosaic virus as a platform for the development of next-generation nanovaccinesстатья
Информация о цитировании статьи получена из
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 1 августа 2016 г.
- Авторы: Gasanova T.V., Petukhova N.V., Ivanov P.A.
- Журнал: Nanotechnologies in Russia
- Том: 11
- Номер: 3-4
- Год издания: 2016
- Издательство: Pleiades Publishing, Ltd
- Местоположение издательства: Road Town, United Kingdom
- Первая страница: 227
- Последняя страница: 236
- DOI: 10.1134/S1995078016020051
- Аннотация: The production of vaccines and other proteins in plants for medical purposes offers a number of advantages over other expression systems. The tobacco mosaic virus (TMV) is an appropriate model for the development of a variety of vectors, including those used for the assembly of chimeric particles carrying heterologous peptides on the surface and inducing an effective immune response. To overcome the problems arising during the assembly of such particles from recombinant subunits of the coat protein, peptide linkers, suppressed stop codons, and proteolytic sites are used. To date, it has been shown that TMV-based nanovaccines provide protection against the viruses of influenza A, foot-and-mouth disease, papilloma, and they are also able to overcome B-cell tolerance for cancer-cell suppression. Genetically modified TMV-based virions can accomodate the ions of various metals and act as affinity agents for protein purification.
- Добавил в систему: Иванов Петр Алексеевич
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Gasanova_16.pdf | Gasanova_16.pdf | 289,0 КБ | 13 апреля 2016 [pivanov] | |
| 2. | Gasanova_16_preprint_Russian_version.pdf | Gasanova_16_preprint_Russian_version.pdf | 268,2 КБ | 5 января 2018 [pivanov] |