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The effect of neural transplantation on audiogenic seizures in rats of different genetic strains [Vliianie neirotransplantatsii na audiogennye sudorogi u krys raznykh geneticheskikh linii.]статья
Статья опубликована в журнале из списка RSCI Web of Science
Информация о цитировании статьи получена из
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Web of Science
Статья опубликована в журнале из перечня ВАК
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 11 сентября 2018 г.
- Авторы: Ermakova I.V., Kuznetsova G.D., Doseva E.V., Petrova E.V., Ioffe M.E.
- Журнал: Журнал высшей нервной деятельности им. И. П. Павлова
- Том: 46
- Номер: 4
- Год издания: 1996
- Издательство: ФГБУ "Издательство "Наука"
- Местоположение издательства: Москва
- Первая страница: 776
- Последняя страница: 786
- Аннотация: The effects of neurotransplantation on development of audiogenic seizures (AS) were studied in Krushinskii-Molodkina (KM) rats genetically predisposed to AS and in Wistar rats especially selected for AS. Within 24 weeks after bilateral combined transplantation of the newborn striatum and cerebellum into the parietal cortex, the AS didn't develop in Wistar rats in 74% of tests. In control Wistar rats with cortical grafts or saline injections into the parietal cortex there were no significant changes in the AS development. In the experimental KM rats the grafting led to the 4-5-times increase in the AS latency. In 50% of rats it decreased the AS severity by 1-2. In the control KM rats these parameters didn't change. It was concluded that it was possible to suppress or decrease the AS development by the transplantation of the newborn striatal and cerebellar tissue into the cortex of rats predisposed to this kind of seizures.
- Добавил в систему: Иоффе Марат Евсеевич