Macrocyclic Antibiotics as Chiral Selectors in High-Performance Liquid Chromatography and Capillary Electrophoresis

Shapovalova, E.N.; Fedorova, I.A.; Ananieva, I.A.; Shpigun, O.A.

Авторы: Shapovalova E.N., Fedorova I.A., Ananieva I.A., Shpigun O.A.
Журнал: Journal of Analytical Chemistry ( Zhurnal Analiticheskoi Khimii)
Том: 73
Номер: 11
Год издания: 2018
Первая страница: 1064
Последняя страница: 1075
DOI: 10.1134/S1061934818110114
Аннотация: Data on the use of macrocyclic antibiotics (vancomycin, teicoplanin, teicoplanin aglycone, and eremomycin) for the enantioseparation of amino acids, various amino acid derivatives, α-phenylcarboxylic acids, β-blockers, and some pharmaceutical preparations in reversed-phase and polar-organic HPLC modes are summarized. It is shown that mixed chiral selectors (eremomycin–vancomycin, eremomycin–bovine serum albumin) combine the properties of two selectors. Eremomycin and macrolides (azithromycin, eryth- romycin, and clarithromycin) are successfully used as chiral selectors in capillary electrophoresis. Aqueous and aqueous–organic supporting electrolytes (SEs) with the addition of eremomycin or nonaqueous sup- porting electrolytes with the addition of a macrolide are used for enantioseparation. The use of nonaqueous supporting electrolytes decreases the adsorption of the selectors on the quartz capillary surface and enables the separation of enantiomers at a low concentration of a chiral selector. Additions of boric acid into the sup- porting electrolyte improve the selectivity of separation.
Добавил в систему: Ананьева Ирина Алексеевна

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Macrocyclic Antibiotics as Chiral Selectors in High-Performance Liquid Chromatography and Capillary Electrophoresisстатья

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