Non-invasive characterization of stationary phases in capillary flow systems using scanning capacitively coupled contactless conductivity detection (sC(4)D)статья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Аннотация:Capacitively coupled contactless conductivity detection ((CD)-D-4) has gained interest recently as an elegant new detection method for capillary electrophoresis and, to a lesser extent, liquid chromatography. However, in recent years, the versatility of this non-invasive detection system for research in materials and separation science has been demonstrated through non-traditional applications, mostly using scanning mode (sC(4)D). This involves the precise measurement of local differences in the conductive response of stationary phases housed within capillary columns. sC(4)D permits physical and chemical interrogation of stationary phases in capillary columns and microfluidic chips, with potential use in liquid and gas chromatography, capillary-zone electrophoresis or electrochromatography. sC(4)D also allows evaluation of chemically-modified surfaces to optimize procedures, coverage and chemical or biochemical activity. This review critically summarizes these developments and highlights the potential for widespread application of sC(4)D, beyond that of simple on-capillary detection. (C) 2010 Elsevier Ltd. All rights reserved.