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Tuning the anticancer activity of maltol-derived ruthenium complexes by derivatization of the 3-hydroxy-4-pyrone moietyстатья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Авторы: Kandioller W., Hartinger C.G., Nazarov A.A., Kasser J., John R., Jakupec M.A., Arion V.B., Dyson P.J., Keppler B.K.
- Журнал: Journal of Organometallic Chemistry
- Том: 694
- Номер: 6
- Год издания: 2009
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 922
- Последняя страница: 929
- DOI: 10.1016/j.jorganchem.2008.10.016
- Аннотация: Organometallic ruthenium(II)-arene complexes coordinated to maltol-derived ligands were prepared and their anticancer activity against human tumor cell lines was studied. In addition, their hydrolysis behavior and reaction with 5′-GMP was tested and compared to the parent compound chlorido[2-methyl-3-(oxo-κO)-pyran-4(1H)-onato-κO4](η 6-p-cymene)ruthenium(II) (Ru-maltol). Improved stability and in vitro anticancer activity at maintained GMP binding capability were observed, in comparison to the Ru-maltol complex. © 2008 Elsevier B.V. All rights reserved.
- Добавил в систему: Назаров Алексей Анатольевич