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Possible role of iron ions in changes in composition of DNA complexes and their magnetic properties in cell cycle processes [O vozmozhnoi roli ionov zheleza v izmeneniiakh sostava kompleksov DNK i ikh magnitnykh svoistv v protsessakh kletochnogo tsikla.]статья
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
- Автор: Khomutov G.B.
- Журнал: Biophysics
- Том: 49
- Номер: 1
- Год издания: 2004
- Издательство: Maik Nauka/Interperiodica Publishing
- Местоположение издательства: Russian Federation
- Первая страница: 140
- Последняя страница: 144
- Аннотация: A hypothesis on the possible role of iron cations in transformations of nucleoprotein complexes at certain stages of the cell cycle was formulated. The central idea of the hypothesis is the proposition that iron ions provide changes in the composition of complexes formed by phosphate groups of DNA, by substituting effectively the cationic amino groups of organic ligands in these complexes by the mechanism of competitive replacement of ligands. Then iron ions can be removed by changing the charge of iron ions bound to DNA during redox reactions and their transfer to mobile complexes or by the formation and subsequent removal of weakly charged magnetic nanoparticles of ferric oxides. These magnetic nanoparticles may be responsible for the magnetic effects in cells, e.g., broad ESR signals inherent in ferromagnetic systems. These magnetic effects were discovered in DNA preparations and in cell cultures at early stages of cell division by L.A. Blumenfeld and coworkers.
- Добавил в систему: Хомутов Геннадий Борисович