Identification of four genes on human chromosome 3 homologous to the known genes on other chromosomes by in silico analysis

Авторы: Rakhmanaliev E.R., Klimov E.A.
Сборник: Proceedings of the Third International Conference on Bioinformatics of Genome Regulation and Structure
Том: 1
Год издания: 2002
Место издания: IC&G, Novosibirsk Novosibirsk
Первая страница: 170
Последняя страница: 172
DOI: 10.13140/RG.2.1.3902.3604
Аннотация: In this work, we analyzed the structure of genomic sequences of human chromosome 3, marked by NotI-STSs. The NotI-STSs had homology with genes localized on other chromosomes that allowed us to suppose the presence of homologous sequences for these genes on chromosome 3. Four nucleotide sequences of human chromosome 3, marked by NotI-STSs (NB1-100, NL3-004, NLM-246 and NRL-402) which have high homology with genes, earlier localized in other genomic regions, were characterized in silico. We have shown that RINZF gene earlier localized on 8q13-q21.1 has the full-length copy on human chromosome 3. For three NotI-STSs (NL3-004, NLM-246 and NRL-402), which were markers of genes LOC132160, ATP11B and ITGA9 on chromosome 3, genes KIAA1157 (12q14.1), HSA9947 (1p36) and SCYA5 (17q11.2-q12) were determined as having homology to the NotI-STS sequences, respectively. Similarity of regulatory regions for three pairs of genes, (LOC132160 / KIAA1157, ATP11B / HSA9947 and ITGA9 / SCYA5), marked by the NotI-STSs, was shown.
Добавил в систему: Климов Евгений Александрович

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