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[Thrombin–a regulator of reparative processes in wound healing]статья
Информация о цитировании статьи получена из
Scopus
Дата последнего поиска статьи во внешних источниках: 28 мая 2015 г.
- Авторы: Strukova S.M., Dugina T.N., Chistov I.V., Markvicheva E.A., Kuptsova S.V., Kolokol’chikova E.G., Rumsh L.D., Zubov V.P., Gluza E.
- Журнал: Bioorganicheskaia khimiia
- Том: 24
- Номер: 4
- Год издания: 1998
- Первая страница: 288
- Последняя страница: 292
- Аннотация: Thrombin, binding to receptors of the protease activated receptor (PAR) family, is involved in wound healing by inducing the reparation processes and regulating the activity of mast cells, which secrete mediators of inflammation. Using thrombin receptor agonist peptide (TRAP-6) for the activation of rat mast cells, effect of several receptors, including PAR-1, on mast cells was demonstrated. It was shown that TRAP increases the concentration of Ca2+ in the cytoplasm of mast cells and regulates cell degranulation, while releasing nitrogen oxide. Thrombin encapsulated in poly(N-vinyl caprolactam)-calcium alginate (PVCL-Ca-Alg) hydrogel films promotes wound healing in rats as demonstrated by the acceleration of fibroblast proliferation and neovascularization.
- Добавил в систему: Струкова Светлана Михайловна