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Calcium magnesium phosphates ceramics for bone regenerationтезисы доклада
- Авторы: Gilyana Kazakova, Tatiana Safronova, Valery Putlayev, Irina Selezneva
- Сборник: yCAM 2019, Conference Abstracts, young Ceramists Additive Manufacturing Forum, April 3-5 2019
- Тезисы
- Год издания: 2019
- Место издания: Université de Mons Mons, Belgium
- Первая страница: 53
- Последняя страница: 53
- Аннотация: The implant cytotoxicity and sufficient porosity to allow the growth of blood vessels, nerve tissue and bone cells proliferation need to be taken into consideration for regeneration of bone tissue in reconstructive and corrective surgery and orthopedics. Furthermore, bone remodeling process depends on complex signaling pathway between osteoblasts and osteoclasts and control mechanisms to achieve homeostasis of their growth and differentiation. Considering the inorganic part of human bone is mainly composed of hydroxyapatite (HAP: Ca10(PO4)6(OH)2) and whitlockite (WH:Ca18Mg2(HPO4)2(PO4)12) minerals, where the WH phase occupies up to 20–35% of total weight and it can recapitulate early-stage of bone regeneration through stimulating osteogenic differentiation,prohibiting osteoclastic activity, and transforming into mechanically enhanced hydroxyapatite (HAP)- neo bone tissues by continuous supply of PO43− and Mg2+ under physiological conditions. In this study, we are obtaining porous resorbable ceramic materials based on calcium magnesium phosphates. Such materials According to the laser granulometry of calcium magnesium phosphate, the nanoparticle are suitable for 3D printing where they have a dark gray color, due to the presence of decomposition products of ammonium acetate. The resulting composite (monomers / powder) structures in the form of a Kelvin structure were exposed to a temperature of up to 1200°C. The study of the metabolic activity of cells in the presence of extracts from the material showed that the materials are able to support the adhesion, spreading and proliferative activity of human mesenchymal stem cells. These samples of biomaterials are biocompatible and do not have a cytotoxic effect on mammalian cells. The resulting ceramic materials are suitable for the creation of resorbable bone implants, including individually designed inorganics bases for the treatment of bone defects.
- Добавил в систему: Сафронова Татьяна Викторовна
Прикрепленные файлы
| № | Имя | Описание | Имя файла | Размер | Добавлен |
|---|---|---|---|---|---|
| 1. | Book_of_Abstracts_yCAM_2019_Kazakova_53.pdf | Book_of_Abstracts_yCAM_2019_Kazakova_53.pdf | 107,9 КБ | 17 апреля 2019 [safronova] |