EFFECT OF CARNOSINE ON CA-2+-RELEASE CHANNELS OF SKELETAL-MUSCLE SARCOPLASMIC-RETICULUMстатья
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 27 мая 2015 г.
Местоположение издательства:Road Town, United Kingdom
Первая страница:619
Последняя страница:623
Аннотация:Carnosine (beta-alanyl-L-histidine), which is present in millimolar concentrations in skeletal muscles, induces Ca2+ release from the heavy fraction of rabbit skeletal muscle sarcoplasmic reticulum by activation of ruthenium red-sensitive Ca2+-release channels. The effect of carnosine is dose dependent, which indicates the presence of saturable carnosine-binding sites in the Ca2+-release channel molecule. Half-maximal Ca2+ release is observed in the presence of 8.7 mM carnosine. In addition, carnosine increases the affinity of sarcoplasmic reticulum Ca2+-channels for Ca2+-release activators (caffeine and adenine nucleotides). We conclude that carnosine is an endogenous regulator of skeletal muscle sarcoplasmic reticulum Ca2+-release channels which modulates the affinity of these channels for different ligands.