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Olfactory system participates in mechanisms of the spike-wave dicharges generation in WAG/Rij ratsстатья
- Авторы: Abbasova K.R., Chepurnov S.A., Chepurnova N.E., Belousova M.L., Chepurnova N.E., van_Luijtelaar G.
- Журнал: 8th European Congress on Epileptology
- Год издания: 2008
- Первая страница: 91
- Последняя страница: 91
- Аннотация: OLFACTORY SYSTEM PARTICIPATES IN MECHANISMS OF THE SPIKE-WAVE DISCHARGES GENERATION IN WAG/RIJ RATS. K. Abbasova*, S. Chepurnov*, N. Chepurnova*, M. Belousova*, V. Blik*, and G. van Luijtelaar *Lomonosov Moscow State University, Russia; and NICI, Radboud Nijmegen University, The Netherlands Purpose: The aim of the present experiment was to evaluate the role of olfactory system in the generation of the spike-and-wave discharges (SWDs) in WAG/Rij rats. Method: Before surgery WAG/Rij rats were anesthetized by Nembutal in a dose of 47 mg/kg. EEG electrodes were chronically implanted into frontal cortex. The mean duration and number of SWDs were calculated. CONAN EEG recording software was used. The deafferentation of olfactory bulbs was induced by i.p. injection of the olfactory epithelial toxin 3- methyl indole (3 MI) in a dose of 200 mg/kg. Results: Significant increase in number of SWDs (p<0.01, by means of Wilcoxon matched pairs test) was found for the treatment group compared to the control rats. Analysis of duration of SWDs showed no significant effects. Conclusion: According to our results we can suggest that olfactory system is include to the mechanisms of generation of the SWDs. I.p. injection of the olfactory epithelial toxin 3-methyl indole (3 MI) induced the increase of the number of the SWDs.
- Добавил в систему: Аббасова Кенул Расим кызы