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Optical tweezers study of red blood cell aggregation and disaggregation in plasma and protein solutionsстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Web of Science,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 9 июня 2016 г.
- Авторы: Lee K., Kinnunen M., Khokhlova M.D., Lyubin E.V., Priezzhev A.V., Meglinski I., Fedyanin A.
- Журнал: Journal of Biomedical Optics
- Том: 21
- Номер: 3
- Год издания: 2016
- Издательство: SPIE, the International Society for Optical Engineering
- Местоположение издательства: Bellingham, WA, United States
- Первая страница: 035001
- DOI: 10.1117/1.JBO.21.3.035001
- Аннотация: Kinetics of optical tweezers (OT)-induced spontaneous aggregation and disaggregation of red blood cells (RBCs) were studied at the level of cell doublets to assess RBC interaction mechanics. Measurements were performed under in vitro conditions in plasma and fibrinogen and fibrinogen + albumin solutions. The RBC spontaneous aggregation kinetics was found to exhibit different behavior depending on the cell environment. In contrast, the RBC disaggregation kinetics was similar in all solutions qualitatively and quantitatively, demonstrating a significant contribution of the studied proteins to the process. The impact of the study on assessing RBC interaction mechanics and the protein contribution to the reversible RBC aggregation process is discussed.
- Добавил в систему: Приезжев Александр Васильевич
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