Cell Sheets of Mesenchymal Stromal Cells Effectively Stimulate Healing of Deep Soft Tissue Defects

Aleksandrushkina, N.A.; Danilova, N.V.; Grigorieva, O.A.; Mal'kov, P.G.; Popov, V.S.; Efimenko, A.Y.; Makarevich, P.I.

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 июля 2019 г.

Авторы: Aleksandrushkina N.A., Danilova N.V., Grigorieva O.A., Mal'kov P.G., Popov V.S., Efimenko A.Yu, Makarevich P.I.
Журнал: Bulletin of Experimental Biology and Medicine
Том: 167
Номер: 1
Год издания: 2019
Издательство: Springer Nature
Местоположение издательства: Switzerland
Первая страница: 159
Последняя страница: 163
DOI: 10.1007/s10517-019-04482-4
Аннотация: We used rat model of splinted defect of the skin and soft tissues to compare the efficiency of mesenchymal stromal cells applied in sheets or in suspension for the treatment of these injuries. Transplantation of mesenchymal stromal cells significantly accelerated wound healing in comparison with the control. In the group treated by application of mesenchymal stromal cell sheets, the defect was closed by day 28, in the group treated with cell suspension by day 35, and in the control group after 49 days. According to histological analysis of the tissue samples, the formation of the granulation tissue and fibrosis occurred earlier after application of mesenchymal stromal cells. Application of mesenchymal stromal cells in the form of cell sheets demonstrated high efficiency, which allowed us to consider this approach as a promis- ing method of healing of skin and soft tissue injuries.
Добавил в систему: Мальков Павел Георгиевич

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Cell Sheets of Mesenchymal Stromal Cells Effectively Stimulate Healing of Deep Soft Tissue Defectsстатья

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